Back in November it was announced that an AI company called DeepMind had near enough cracked the problem of protein folding - that is they had managed to successfully predict the 3D structures of complex biochemical molecules by only knowing the 2D sequence of amino acids from which they are made. They are not the only team to use machine learning to approach the vast amounts of data involved. But only last week, they released the source code and methodology behind their so called AlphaFold 2 tool for free. And today they have published, via a paper in the journal Nature, a simply huge database of predicted structures including most of the human proteome, and 20 other model species such as yeast and mice. The possibilities for any biochemists are very exciting. As DeepMind CEO Demis Hassabis tells Roland Pease, they partnered with the European Molecular Biology Laboratory to make over 350,000 of these protein predictions available to researchers around the world free of charge and open-sourced. Dr Benjamin Perry of the Drugs for Neglected Diseases Initiative told us how it may help in the search for urgently needed drugs for difficult illnesses such as Chagas disease. Prof John McGeehan of the Centre for Enzyme Innovation at Portsmouth University in the UK is on the search for enzymes that might be used to digest otherwise pollutant plastics. He received results (that would have taken years using more traditional methods) back from the AlphaFold team in just a couple of days. Prof Julia Gog of Cambridge University is a biomathematician who has been modelling Covid epidemiology and behaviour. In a recent paper in Royal Society Open Science, she and colleagues wonder whether the vaccination strategy of jabbing the most vulnerable in a population first, rather than the most gregarious or mobile, is necessarily the optimal way to protect them. Should nations still at an early stage in vaccine rollout consider her model? And did you know that elephants can hear things up to a kilometre away through their feet? And that sometimes they communicate by bellowing and rumbling such that the ground shakes? Dr Beth Mortimer of Oxford University has been planting seismic detectors in savannah in Kenya to see if they can tap into the elephant messaging network, to possibly help conservationists track their movements. Also, One listener finds herself unconcerned about much of the world’s problems, it leaves her wondering: am I a psychopath? Inspired by a previous episode on empathy, this listener asked is it true that psychopaths don’t empathise and what are the character traits of psychopathy? Marnie Chesterton talks with a diagnosed pro-social psychopath to find out. She also pays a visit to the Netherlands Institute for Neuroscience and gets into an MRI scanner to discover what is happening in her brain when she empathises. Studies suggest around 1 percent of the general population exhibit traits associated with psychopathy and that rises to 3-4 percent in the world of business. But is this really the case? Why is there so much stigma associated with psychopathy and do psychopaths even exist or is it just a convenient term to label those whose emotional range sits outside of the “norm”? Presented by Marnie Chesterton and produced by Caroline Steel for the BBC World Service. Guests: Julia Shaw Jim Fallon Valeria Gazzola Kalliopi Ioumpa Image: Protein folding Credit: Nicolas_/iStock/Getty Images

This week the UK parliament voted to accept the Government’s continued cap on Official Development Aid. This disappointed many researchers around the world, funded directly and indirectly through various scientific funding structures enabling international collaboration on some of the global challenges facing all of us. These funding mechanisms make for a small fraction of the overall amount, but they have been hit hard, with many projects closing altogether. There had been hope amongst the scientific community that the cap – from 0.7% down to 0.5% of the UK’s Gross Domestic Income – might have been in place just for a year. But it seems like the criteria set to judge when the level of aid might rise again imply that it is unlikely to happen for several years at the earliest. What, asks Science in Action, does that mean to the world of scientific collaboration on such topics as climate change, contagious disease, and emergency planning? Researchers Chris Trisos and Jenni Barclay, with journalist Robin Bisson of Research Professional News, update us on the story. Also, In Zambia, where covid testing remains scarce, a project run by Boston University’s Christopher Gill has been estimating the prevalence of covid in the capital Lusaka by taking nasal swab samples from the noses of around one in five of those recently deceased, in the morgue of a major hospital. Tantalisingly, his team have seen over the last few months a sharp rise in cases to the extent that in June, nearly 90 percent of the cadavers tested positive for covid. But as Chris describes, unrelated to the UK cuts, their funding has now run out, so where the graph leads from here we may not learn for a long time. Anyone who has ever taken the Christmas lights out of the cupboard, only to discover they’re hopelessly tangled, will sympathise with this week’s listener Eric. He has a 45m garden hose that always seems to snarl up and snag when he waters his garden, and he wonders what he’s doing wrong? Marnie starts by discovering the important difference between tangles and knots, as she scales a cliff with an experienced climber who explains the way you tie rope is a matter of life and death. Physicists are also fascinated in how string becomes jumbled up and one man has even won an IgNobel award for his work in this field. Doug E Smith discovered that if you put a piece of string in a box then spin it around, its length, thickness and how long you shake the box for, all determine whether it will tie itself up. Not only that, the more the string becomes twisted, the more likely it is to cross over itself and become impossible to untangle. While tangles might be annoying in hair or cables, they’re also a fundamental part of human life. Our DNA is constantly folding itself to fit inside tiny spaces – there are two metres of the stuff inside every cell, where it’s packed down tightly, before it must untangle and duplicate for those cells to divide. It does this with the help of specific enzymes, and when the process goes wrong it leads to cell death. But scientists are also studying molecular tangles that might benefit us humans, and creating nano-sized knots that can be turned into nets or meshes with incredible properties. (Image: Getty Images)

Scientists say the record-breaking Pacific North-West heatwave of recent weeks must have been caused by human induced climate change, but as Geert Jan van Oldenborgh explains to Roland Pease, despite a herculean effort to analyse the event in just a week, the precise mechanism to cause such an extreme and sudden event is so far bewildering climate modellers, exceeding even worst expectations. Looking to the skies, Rosita Kokotanekova of the European Southern Observatory and colleagues have been getting excited about the discovery of a comet maybe twice as large as any observed before. Being so big, it has been spotted much further out from the sun and – if the best telescopes can be convinced to join the fun – will provide astronomers a chance to observe the core of the comet before the solar heat induces a gaseous coma to form as it nears the point in its orbit closest to the sun. It will be around for the next decade before continuing its several million year journey around our mutual star. But it won’t get terribly close to earth, at least not as close as lumps of an asteroid that fell onto a driveway in the UK earlier this year. Dr Ashley King of the UK’s Natural History Museum is leading a consortium of scientists (benefitting from a rapid research grant by the UK’s STFC) who have now officially classified it and named it. The Winchcombe meteorite is a CM carbonaceous chondrite, meaning it represents the unspoilt early building blocks of the solar system. Falling like 4.5 billion year old leftover celestial lego, only a few are known around the world but perhaps none have been in scientists hands in such a short period of time, continuing its pristine survival. Dr Pablo Tsukayama has published a preprint paper announcing a new variant of interest in the ongoing evolution of the SARS-CoV2 virus. Now named by the WHO as the Lambda variant, it seems it has driven the pandemic for much of this year in Peru – as much as 80% of cases – and large fractions of the outbreak elsewhere in South America. But as Pablo suggests, the reason we don’t know as much about it as for example the Alpha or Delta variants is likely because it hasn’t thus far affected the countries best equipped to do the analysis. Maybe that could change. Standing takes less energy than walking, so why does it feel more tiring? At least, it does for CrowdScience listener Nina. She can march for hours without getting tired, but her legs and feet get achy after just a short time standing still. It’s one of three walking-themed questions CrowdScience is tackling this week. Taking inspiration from our active listeners, Marnie Chesterton walks up a hill with Caroline Williams, author of a new book about why humans are designed to move. We find out how our whole system – body and brain – works better when we’re walking, compared to standing still. We’re probably set up this way because of our evolutionary history: hunting and gathering needed us to be ‘cognitively engaged endurance athletes’. We stop for a break.. but is it true that we shouldn’t sit down to rest during a walk? Our listener Sarah is a keen hillwalker but likes to take the weight off her feet every now and again. Her hillwalking friends disapprove, saying she should rest on her feet. Is this a myth CrowdScience can bust? And finally a question from listener Matteo: is walking or running better for your health? Numerous studies show significant benefits to both forms of exercise, but in the end, the best kind of exercise is the one you’re motivated to do. Image: Wildfires in Lytton, British Columbia Credit: ProPics Canada Media Ltd/Getty Images

The Natural History Museum in London holds a massive collection of insects. It asked researchers at the Diamond light source, a facility near Oxford, to develop a high throughput X-ray microscope to take 3D scans of them all. Roland Pease has been to see the new technology in action. Many people seeking compensation for the impacts of climate change are turning to the law courts. Successes so far have been few. Oxford University’s Friederike Otto, who specialises in connecting weather extremes to the greenhouse effect, has just published a paper looking at the challenge in bringing successful climate lawsuits. Spacecraft will be returning to Venus in the next decade with the recent approval of two NASA missions to the planet, and one from the European Space Agency, ESA. Philippa Mason of Imperial College is a planetary geologist on that mission, Envision. She plans to use radar to peer through that dense and interesting atmosphere to follow up evidence of volcanic activity and tectonics on the surface beneath. A few years ago synthetic biologist Jim Collins of Harvard found a way to spill the contents of biological cells onto … basically … blotting paper, in a way that meant by just adding water, all the biochemical circuitry could be brought back to life. With a bit of genetic engineering, it could be turned into a sensor to detect Ebola and Nipah viruses. His team have kept developing the idea, and this week they report success in a smart face mask that can detect SARS-CoV-2 in your breath. Also, Food. For all of us it is a basic necessity and for those lucky enough, it is something we spend a lot of time planning and enjoying. CrowdScience listeners certainly have a lot of food related questions; in this buffet of an episode Marnie Chesterton opens the fridge door to pick the tastiest. Starting with the seemingly simple question of what makes us feel hungry, and ending in outer-space, Marnie investigates flavour, nutrition and digestion. After a year when watching TV has become a core activity for many people stuck in their homes, one listener wants us to find out if eating food whilst watching the TV affects our perception of taste. We then journey to the skies and ask if it is true that food tastes blander on aeroplanes, what does that mean for astronauts’ mealtimes? Back on earth, Marnie explores whether humans are the only animals that season their food. Tuck in your napkins and prepare to feast on a smorgasbord of scientific snacks. (Image: Hairy Fungus Beetle - Prepared by Malte Storm. Credit: Diamond light Source Ltd)

This week Jesse Bloom of Seattle’s Fred Hutchinson Cancer Research has published an account of some DNA sequence data he located in an internet archive, despite it having been removed from the US NIH’s Sequence Read Archive. He tells Roland Pease of its significance to our understanding of the beginning of the Covid pandemic, but also, of more general interest, to what it might tell scientists about the full availability of relevant virological evidence. Elsewhere, Elena Zavala of the Max Planck Institute for Evolutionary Anthropology in Leipzig has been using new techniques for sequencing tiny fragments of mitochondrial DNA found in layers of mud to trace a long narrative of different evolutionary species of human and animal and their changing fortunes. As she describes in a paper published in Nature, sediments from different depths of the floor of the famous Denisova cave tell a long story of different humans (Denisovan and Neanderthal), bears, hyenas and other animals living there over different periods in the last 250 thousand years. Over in the journal Science, several papers describe a new type of early hominin found in Nesher Rambla, Israel, that may be yet another instance of a human species that didn’t quite make it. As Marta Lahr, professor in human evolutionary biology at Cambridge University tells Roland the new findings all point to the bigger question – given the similar ages, technologies and even neighbourhoods that all these types of hominin shared, just what was it about our own direct ancestor species that enabled us to take over the world? Since almost the beginning of the Covid pandemic, in some parts of the world, the drug Ivermectin has been repurposed as a therapy against the disease, with some even believing it to convey protection against infection – a situation not without tragic consequences. The evidence for any meaningful effect has been less than obvious to most scientists and health authorities. Not the first controversial drug in the story of Covid-19, the discourse has led to abuse directed at scientists and officials, and scathing arguments across social media. As Oxford University’s PRINCIPLE trial this week begins to include Ivermectin in its investigations, BBC Reality Check’s Jack Goodman reports on the Ivermectin’s tortuous path. It took a while before it was officially recognised as a major symptom of Covid-19, but loss of smell has affected up to 60 percent of people who have had the virus. And for a significant portion, smell continues to be an issue for weeks or months after their recovery. So what’s going on and how can you get your sense of smell back? We tend to think of our sense of smell as something universal – if it smells bad to me, it probably does to you but that is not the case for CrowdScience listener Annabel, who wonders why things other people love to sniff, she finds disgusting. Anand Jagatia investigates the science of smell, gets up close to the world’s smelliest plant and finds out if smell training can help those with long-term issues after Covid. (Image: Getty Images)

Dr. Clare Jolly and colleagues have been looking at how the first of the major covid variants – alpha - evolved to be more transmissible. Whilst a lot of attention has been on the spike binding areas of the virus and the effectiveness of antibodies from either vaccine or prior infection, their preprint paper this week reports how the virus evolved an ability to inhibit our bodies' innate virus response once it has infected a cell. Prof Dan Shugar and colleagues have been studying the conditions that led to the tragic rock and ice avalanche in February in Chamoli, Uttarakhand. 27 million cubic meters of rock and ice broke off the steep mountainside and plummeted almost two km down into the valleys below. Using satellite, seismic and video data the scientists have investigated the sequence of events that led to the tragic deaths of 204 people in the floods that followed. It was a thankfully rare combination of geography and geology and events, but highlights the care that should be taken when building the growing number of hydroelectric plants in high mountainous areas. But avalanches don’t just happen in mountains. A year before in a canyon under the sea near the outflow of the Congo river, a sediment avalanche rumbled on for almost 2 days along some 1,100km of the ocean floor. And as Prof Pete Talling describes, whilst it didn’t trigger a tsunami, it did sever cables supplying internet connectivity between South Africa and Nigeria. And the BBC’s Samara Linton reports on research into a type of DNA you perhaps haven’t heard of – Z-DNA. It winds the other way to what we consider normal DNA, and scientists are finally beginning to understand its role in many human diseases, including cancer, with some future promise of novel therapeutics. Also, Why do I have such a sweet tooth? They say life is sweet. Well that’s certainly the case for CrowdScience listener Trevor in Poland who wonders why he can’t stop reaching for the cookie jar. He grew up drinking fruit juice with added sugar but wonders whether his genes could be as important as his environment when it comes to his sweet tooth, especially since his wife seem to be satisfied with mainly savoury snacks. The World Health Organisation says added sugar should constitute a maximum of 5% of our daily energy intake because it can contribute to diabetes, heart disease and obesity. But that’s tricky when you consider it’s now in everything from salad dressings, to savoury sauces. Manufacturers have been promoting sugar alternatives for decades but recreating the unique taste and feel of it in the mouth are a challenge. Marnie Chesterton gets to try a brand new innovation – a so-called ‘rare’ sugar that has 70 percent of the sweetness but almost none of the calories. In nature, allulose is found in figs, but one producer has discovered a way to make it in the lab. Does it taste as good as it claims? Whilst switching to alternative sugars and sweeteners may reduce the calories, some researchers claim that tasting sweetness, wherever it comes from, can disrupt the body’s mechanism for regulating blood-sugar levels, increasing the risk for conditions like diabetes. (Image: Getty Images)

On Science in Action this week Nasa scientists have observed that the Earth’s Energy Imbalance has doubled in just 15 years. As greenhouse gas atmospheric concentrations have risen, so too has the difference between the total amount of energy being absorbed from the sun, and the total amount being re-radiated back into space. Meanwhile, as we all heat up, scientists at the LIGO Gravitational Wave Observatory have managed to do something very cool with their mirrors. Such is the precision with which the detectors have been engineered, they have managed to effectively reduce the temperature of one of the big 10kg reflectors to such an extent that it betrays its quantum state as if it were simply one big subatomic particle. So what? Roland Pease finds out. Also, Scales don’t come planet-sized, so answering a question from David in Ghana may require some ingenuity, after all, calculating the weight of the Earth is a huge task. Using a set of weighing scales and a 400 year-old equation, Marnie Chesterton attempts to find out just how much the Earth weighs and is it getting heavier or lighter over time? But how would a planet gain or lose mass? Which tips the scales: meteorites falling from space or gases constantly escaping from our atmosphere? And does the answer have any implications for the future of Earth? Could the atmosphere eventually run out? (Image: Getty Images)

Researchers map where the riskiest areas are for viruses to jump from bats into humans. Also, synthetic bacteria with unnatural DNA, and the origin of the humble watermelon. David Hayman of Massey University in NZ and colleagues have published in the journal Nature Food a study highlighting areas of the world where zoonotic transmission of coronaviruses are most likely to occur between humans and bats of the type most suspected of being the origin of the current SARS CoV2 virus. There are a lot of hotspots combining fragmented forest, livestock farming, human habitation, and populations of horseshoe bats. It is, as he says, just part of the evidence suggesting a natural origin in the areas of northern south-east Asia and southern China. Jason Chin, Wes Robertson and team at the Laboratory of Molecular Biology have been tinkering with their work on synthetic organisms. By rewriting the dictionary of DNA itself, their new molecular alphabet is able to encode far more elaborate and innovative functions than even nature has ever produced. Publishing this week in the journal Science, their latest bacterium is even capable of being completely immune to viral infection. But as they describe, this could be just the start of what the new technology could deliver in terms of new materials and medicines. Meanwhile, Susanne Renner has been tracking down some of human beings’ earliest genetic engineering. The selection and breeding of various fruits to produce sweet, sweet watermelon was long suspected to have originated in Africa, the question was where and when? Using a combination of genetic sequencing, ancient Egyptian art, and early modern paintings, she describes to Roland how what we now know as Sudan likely played a part in the story. What is the point of menstruation? It's a topic that's taboo in many cultures, yet it's also something nearly every woman experiences – on average upwards of 400 times throughout her life: menstruation. Responding to a flood of questions from our CrowdScience listeners, Marnie Chesterton seeks to unpack how periods affect women physically, mentally and societally. Why did humans evolve to have periods when fewer than two percent of mammals share our experience of menstrual cycles? Is it really a good use of our limited energy reserves? What can the little Egyptian spiny mouse teach us about PMS symptoms? We hear why periods may reduce the number of faulty embryos that implant and how more menstrual cycles may even increase our chances of developing certain types of cancer. Finally, as the number of periods a woman has over the course of her life has more than quadrupled since the pre-industrial era, Marnie asks: Do we really still need to have them? (Image: Horseshoe bat Credit: Getty Images)

The latest Nyiragongo eruption was not entirely unexpected, the volcano’s lava lake inside the crater had been building up for years. Local volcanologists say it was only a matter of time before an eruption occurred. The big concern was where the flank of the volcano would be breached as the city of Goma rests under the volcano and there are potential fissures even within the town. However there are still questions over the effectiveness of seismic monitoring in the area, North Kivu. The Goma observatory has been unable to carry out this work due to a lack of funding. And monitoring is further complicated by the region’s long running civil war, with rebel groups often camped around the volcano. We hear from Dario Tadesco and Cindy Ebinger. Who have both been monitoring developments. Cyclone Yass was the second Cyclone to hit India within a week. Are these events becoming more common and are they related to rises in global temperatures? Climatologist Roxy Koll has been monitoring the situation. Greenland’s pristine glaciers might not be so pristine. Jemma Wadham from Bristol university and her team have found unexpectedly high levels of Mercury in meltwaters - similar to those from industrial pollution. They say research now needs to focus on the impact for wildlife and people in the Arctic region. And the elusive Sowerby’s beaked Whale doesn’t travel very much despite pockets of the species being found across the Atlantic. Kerri Smith has been researching this species, which is rarely seen alive. Using samples from whales beached or caught accidentally she was able to build up a picture of their distribution. As millions more of us move to live in densely populated cities, we almost inevitably face living in closer proximity to our neighbours. Neighbour noise can certainly be a source of annoyance – but could it even be damaging to our health? Increasing evidence suggests that unwanted noise can cause sleep deprivation, distraction and annoyance, as presenter Anand Jagatia finds out. He discovers that noise annoyance has a small but significant impact on our wider health – including our cardiovascular system – but that annoyance is not necessarily down to sound alone. Factors such as perception of the neighbourhood and relationships with our neighbours also play a part. CrowdScience has examined living with unwanted noises before, and we revisit our trip to the acoustics lab at the University of Salford in Manchester, UK. Here, we meet the researchers and engineers investigating the best ways to make our homes more pleasant for our ears whilst still maintaining the ‘buzz’ of city life. (Image: Getty images)

A brain-computer interface allows a severely paralysed patient not only to move and use a robotic arm, but also to feel the sensations as the mechanical hand clasps objects . We hear from Jennifer Collinger at Pittsburgh University’s Rehab Neural Engineering Labs. And Nathan Copeland, who has been controlling the robotic arm with his thoughts via a series of brain implants. Ralph Baric of the University of North Carolina tells us about the development of a multi-component vaccine that would be effective not just against the current coronavirus outbreak and its variants, but also future outbreaks from SARS-like coronaviruses that we don’t even know about yet. Blood clots, thromboses, have been a problem for a small number of people following Covid vaccination Paul Knöbl, and a team of medics in Vienna have worked out the link between vaccination and clot development. They now have a method to treat such clots – so they should not be fatal. And how did fungi and plants come to live together? Symbiotic relationships between the two are a key component of the evolution of life. Melanie Rich of the University of Toulouse has been looking at the present day genetic markers which allowed plants and fungi to help each other as they first colonised land millions of years ago. Also...You are a star. Literally. You are a carbon-based life form and those atoms of carbon in the molecules that make up your cells were formed by a nuclear fusion reaction at the heart of long dead stars. That goes for the oxygen in your lungs too. And the red blood cells that carry that oxygen to your tissues? They contain haemoglobin, and nestled at the heart of each molecule is an element (iron) formed by a supernova - the fiery explosion at the death of a star. Your body is a walking, thinking museum of some of the most violent events in the universe. This, as CrowdScience host Marnie Chesterton discovers, isn’t as special as it sounds. All of the stuff on the earth - the elements that make clouds and mountains and mobile phones – they all have an origin story. CrowdScience tells that story, starting with the big bang and ending with physicists, creating new elements in the lab. Find out the age of the elements and the distance they have travelled to make their current home on earth. (Image: Artificial tactile perception allows the brain-computer interface user to transfer objects with a robotic arm at twice the speed of doing it without the feedback. Credit: UPMC/Pitt Health Sciences Media Relations)

We wouldn’t drink dirty water so why do we put up with polluted air? Researchers are calling for a major rethink on our attitude to air quality. Professor Lidia Morawska, from the Queensland University of Technology, says attention to air quality during the Covid pandemic has shown how levels of airborne disease can be reduced. Sam Wilson from the UK Medical Research Council, University of Glasgow Centre for Virus Research has been investigating genetic mechanisms associated with susceptibility to Covid infection. His team has identified a molecule that detects SARS-COV-2 when it starts to replicate in our cells. However, not all humans have this protective mechanism, which may help explain why some people become very ill with Covid and others have little if any symptoms. Many Europeans lack this protective molecule, whereas the vast majority of Africans have it. The difference can be seen in cell cultures. However, the lack of diversity in the cells used in experiments worldwide can be a serious problem when looking at genetic differences as Samara Linton reports. Nuclear material buried beneath the doomed Chernobyl nuclear power plant is becoming more active Neil Hyatt Professor of Nuclear Materials Chemistry at Sheffield University says it’s a small increase but needs to be monitored. And There are over 400,000 species of plant on earth, they’re on every continent including Antarctica. But humans only regularly eat about 200 species globally, with the vast majority of our nutrition coming from just three species. Many of the fruits, leaves and tubers that other plants grow are packed full of toxins that are poisonous to us, and would make us very ill if we ate them. But could we take out the poisons and create new, edible crops? That’s what CrowdScience listener Marija wants to know. Crowdscience dives into this topic, and uncovers the that many crops are poisonous, and why so few plants are eaten globally. Host Anand Jagatia finds that even the modern scientific processes of crop breeding are very slow. But science can now engineer plants at the genetic level by adding, silencing or removing specific genes. This ‘genetic modification’ is hugely controversial but can be highly effective. Anand finds a man who has spent decades making cotton seeds edible by removing the poisons they naturally produce in their seeds. This GM crop could help fend-off starvation. But sometimes introducing poisons can be as important as removing them, as we find in the genetically modified ‘BT eggplants’ in Bangladesh. The new gene makes the vegetable toxic to a major insect pest, so they are much easier to grow. But GM crops are not the perfect solution. They have problems of gene escape, can increase the use of environmentally damaging herbicide, and can be open to monopolisation. In some countries, particularly in Europe, GM crops are hugely controversial. Anand finds out whether these concerns stand up to science and looks at the counterpoint in developing countries in Africa, South Asia and elsewhere, where local farmers like Patience Koku in Nigeria have little time for some of the concerns around GM, particularly as they see poor harvests, poverty and starvation as the more pressing problems. (Photo by Sean Gallup/Getty Images)

Analysis of the 78,0000-year-old fossil of a Kenyan boy reveals he was likely buried with care and attention, the body wrapped and laid to rest supported on a pillow. Maria Martinon-Torres, of the National Research Centre on Human Evolution in Burgos, Spain, and a team from Kenya and Germany used techniques from paleontology and forensic science to reveal his story from the fragile remains. A promising malaria vaccine is to enter trials which could lead to it being used globally to vaccinate children. Merheen Datoo, Oxford University’s Jenner Institute, explains malaria vaccines have been in development for 100 years. Research from these helped covid vaccine development and the success of covid vaccines may now help to speed up the rollout of malaria vaccines. Covid vaccines may also help to treat those who have symptoms of long covid – a range of immune system issues that develop sometimes months after the initial infection. Yale University immunologist Akiko Kawasaki is embarking on a research project to assess the impact. If you’d like to take part, have yet to be vaccinated, and live in Connecticut in the US, email covidrecovery@yale.edu. And in India scientists are calling on the government to make all data on Covid more widely available. At present Indian bureaucracy means statistics on infection rates, variants and recovery are not distributed widely. Science journalist TV Padma says greater access to the data could help more scientists come together to work on solutions to India’s Covid crisis. And, Have you taken classes to learn a new sport or musical instrument or a language? It’s hard work! Why is it that as children we effortlessly absorb new skills and we don’t as adults? That’s what 50-something listener Gary Grief wondered about playing guitar. Do you need to play more frequently as an adult to attain the same level of expertise? Does the 10,000-hours theory still apply? Presenter and budding tabla-player Anand Jagatia embarks on a musical journey to discover what neuroscience can tell us about muscle memory and learning. Do musicians and sportsmen share the same challenges? By understanding what’s happening in the brain, can we learn how to learn better? With tabla-teacher Satvinder Sehmbey, neuroscientist Dr Jessica Grahn, viola-player Dr Molly Gebrian and sports scientist Prof Yannis Pitsiladis. (Image: An artist’s interpretation of Mtoto’s burial Credit: Fernando Fueyo)

When Apollo 11 astronaut Michael Collins – who passed away this week – looked down on the earth from lunar orbit during those days in 1969, he saw more ice and a smaller liquid ocean than you would see today. Of the 200,000 glaciers outside of the polar and Greenland ice sheets, their melting in the last two decades accounts for about a fifth of the sea level rise we are also seeing. Thus according to a paper published this week in the journal nature by, amongst others Bob McNabb of Ulster University who describes to Roland how and why these numbers are more certain than others before. As fellow earth observation expert Anna Hogg adds, the work synthesises years of data from almost half a million images of glaciers taken from space, and provides our best handle yet on our accelerating loss of this finite and dwindling natural feature. Researchers at Kew in the UK and in Sierra Leone have re-discovered a species of coffee plant once thought lost. As Marnie Chesterton reports, climate change threatens many coffee crops around the world as the most popular variety – arabica – needs cool high altitude conditions which are going to become more scarce. But after a long and arduous search, the researchers have discovered a more resilient variety that might not only save the morning brew for many, it may even prove agriculturally and even economically transformative for some African economies. And whilst many of us watch the antics of NASA’s Martian helicopter, Ingenuity, as it whizzes across the distant plains of “Wright’s Field” aerodrome on Mars, some are watching with more trepidation than others. In 6 years’ time, Zibi Turtle, Principle Investigator of NASA’s Dragonfly mission, hopes to launch a much larger octocopter drone to Titan, moon of Saturn. As she describes to Roland, the challenges are huge, not least because dragonfly will carry all its instruments on board as it hops around, finding new landing sites autonomously. And communicating with Earth will take a whopping hour each way. When eating a blackberry one day, CrowdScience listener Charles got a tiny seed stuck in his teeth. That got him wondering: why are seeds the size they are? Why does a blackberry have dozens of tiny pips, while a peach has one huge stone right in the middle? Plant seeds have been around for hundreds of millions of years, so they’ve had plenty of time to shapeshift into wildly different forms: from dust-like orchid seeds to giant coconuts. This evolution has been a long and intricate dance with wind, water and animals; we ask how different kinds of seeds might respond to today’s environmental threats and rapidly changing ecosystems. And we go in search of the world’s biggest seed, the coco de mer: native to just two remote islands in the Indian Ocean and weighing up to 18kg, how did this seed evolve to be so much bigger than any other? (Image: The lunar module , carrying Neil Armstrong and Buzz Aldrin, ascends back up to the command module with Michael Collins. It is often said that Michael Collins is the only human, living or dead, who is not in this photograph. Credit: Michael Collins / NASA)

As Covid cases surge almost beyond belief in India, how much is to do with social distancing, and how much to do with the mutations to the original virus? Ramanan Laxminarayan talks to Roland from Delhi about ways in which the huge second wave could and could not have been predicted and avoided. Suggestions of the latest variant to make the headlines, B1.617, have got virologists such as Ravindra Gupta working hard to identify the clinical significance of the latest combinations of mutations. In the journal Science, Stephen Chanock of the US Cancer program reports work with colleagues in Ukraine looking at the long footprint of radiation dosing from the Chernobyl nuclear disaster, 35 years ago this week. In the first of two papers, they find a definite footprint of radiation damage accounting for the many sad cases of thyroid cancer in people alive in the region at the time. But in another study, they looked at whether any higher level of mutations could be detected in the germlines of children conceived subsequently to parents who had experienced radiation in the disaster. While the parents' own health is often affected, 35 years on, thus far their offspring show no widespread elevated levels of disease, as was commonly expected. And in the week that the world witnessed a guilty verdict delivered in the trial for the murder of George Floyd in the US, David Curtis of the University of Utah and colleagues report in the journal PNAS a study that suggests the widespread media coverage of acts of racial violence, including deaths at the hands of police, leads to poorer mental health in Black Americans. As the BBC’s Samara Linton reports, the study involved google search data over five years up to 2017, and nearly 2.3 million survey respondents. Also, most of us don’t like to dwell on our toilet habits, but this week we have gone down the drain to discover what wastewater can tell us about our health. It’s been more than a year since scientists across the globe started to track the spread of Covid-19, with help from home test results and hospital data. Marnie Chesterton investigates the latest tool in their arsenal: sewage. Listener Kevin has heard how human waste can be monitored to check for virus levels, and wants to know if it can also be used to stop the disease in its tracks? Although the coronavirus has been discovered in people’s poo, so far there’s little indication it’s actually being spread through the water system. But by taking regular samples from different parts of cities, authorities are now able to accurately predict a local peak weeks before the population shows signs of sickness, then take immediate measures to alert them. In Detroit we hear how environmental engineer Professor Irene Zagoraraki used this method to detect a rare strain of Herpes which doctors didn’t even know was a potential problem. We talk to Professor Nick Thomson from the Wellcome Sanger Institute, who sequenced the genome of the bacteria that causes cholera, to understand how it has crisscrossed the globe. He discovered that the pandemic currently devastating Yemen actually originated in Asia. It’s a discovery that has changed how the WHO is thinking about this killer disease and could have important implications for vaccination programmes. But our effluent can also pose environmental problems, and Professor Andrew Johnson from the UK’s Centre for Ecology and Hydrology explains there are now as many as 300,000 chemicals that could threaten natural habitats. While authorities try to test each one individually, he’s concerned they may have different effects when they mix in wastewater, and current monitoring systems don’t take this into account. Not only that, but some of these substances contain silver nanoparticles, which Professor Juliane Filser tells us stick around in soil for ever, threatening organisms and bacteria at the base of the food chain Image: NurPhoto/Getty Images

One of our most complete ancient ancestor’s fossils has been transported to the UK from South Africa in order to be scanned at the Diamond Light Source. Roland Pease investigates what these scans could reveal about the human story. Professor Corinne Le Quéré explains how she managed to look past the 7% reduction in human emissions caused by the pandemic in 2020 to reveal the impact of the Paris Climate agreements, and explains what more needs to be done. Roland speaks with anthropologist Dr. Rolf Quam, who has studied the inner ears of fossilised Neanderthal skulls to reveal they may have evolved the ability to hear the complex sounds of spoken language separately to our own species. Dr. Emma Hodcroft discusses the Brazilian P1 COVID 19 variant that is spreading around the world. And, The sudden agony of stubbing a toe or burning a finger can make even the most polite among us swear our heads off. It’s like a reflex, a quick-release valve for the shock. But why do expletives give us such a sense of relief? Why does it sometimes feel so good to swear? We set out to explore the science of swearing, prompted by a question from our listener Gadi. Psychological studies have shown bad language can relieve pain, or even make us stronger; we test out these theories for ourselves, and try to figure out why certain words are charged with such physical power. We don’t just use strong words in shock or anger, either. They can help us to bond with others, to express joy, solidarity, or creativity. And although people curse all over the world, it’s not quite the same everywhere. We hear what people like to swear about in different countries, and whether swearing in a second language can ever be quite so satisfying. (Image: Little Foot Skull. Copyright: Diamond Light Source Ltd)

Although vaccines will go a long way to reducing the number of cases of Covid, there’s still a need for other approaches. One of these could be an engineered biomolecule, designed by virologists Anne Moscona and Matteo Porotto, that blocks SARS-CoV-2 precisely at the moment it tries to enter cells in the nose and upper airways. Roland Pease talks to Anne Moscona about this “molecular mask”. We’re already beginning to see really encouraging analyses showing that Covid vaccines are performing as well in the real world as was promised by last year’s trials. Shane Crotty of the La Jolla Institute for Immunology discusses progress so far and the question of one dose or two with Roland. Lives can be saved if there’s an early warning system for earthquakes and tsunamis. Seismologist Zhongwen Zhan at CalTech has been experimenting with a newly installed 10,000 km cable laid along the Pacific coasts of north and south America by Google, all the way from Los Angeles to Santiago. What he was looking for were subtle changes in a property of light that’s important to IT engineers, and can detect subsea earthquakes. We are still sending too much waste to landfill sites. At the Commonwealth Science Conference this week Veena Sahajwalla of the University of New South Wales explained how she is creating small scale factories that can use discarded objects such as ceramics and textiles to make new products. Listener Paula from Kenya is a computer scientist, she can’t help but notice the inequality in her workplace. With only 1 in 10 countries having female heads of state, there is no doubt that men are in charge. Paula wants to know if there is any scientific underpinning to this inequality? Perhaps it can be explained by our brains and bodies? Or does evolution weigh in? Or maybe it is all down to society and the way we raise our boys and girls. The toys and ideals we give our children must surely have an impact. And most importantly, if we want a world run by men and women equally, how can we get there? We hear how Iceland became the most gender equal country in the world. Presented by Marnie Chesterton. Produced by Caroline Steel for the BBC World Service (Image: Getty Images)

A paper in the BMJ shows that deaths from Covid 9 are being massively overlooked in Zambia. The new data come from post-mortem tests at the University Hospital mortuary in Lusaka, showing that at least 1 in 6 deaths there are due to the coronavirus; many of the victims had also been suffering from tuberculosis. Chris Gill of Boston University’s Department of Global Health, and Lawrence Mwananyanda, chief scientific officer of Right to Care, Zambia, discuss their findings with Roland Pease. New variants of concern continue to be reported, such as the one labelled B 1 1 7 in the UK, or B 1 351 identified in South Africa. Geneticist Emma Hodcroft, of the University of Bern, talks about seven variants that have been found in the US. Although all these variants are evolving from different starting points, certain individual mutations keep recurring – which suggests they have specific advantages for the virus. Her co-author Jeremy Kamil, of Louisiana State University Health Sciences Center in Shreveport, explains how he can watch the viruses replicating inside cells. Much of the United States, as far south as Texas, and Eurasia, has been gripped by an extraordinary blast of Arctic weather. Roland hears from climatalogist Jennifer Francis, of the Woodwell Climate Research Center, about the Arctic’s role in this weird weather. Life, in the form of sponges, has been discovered hundreds of metres under the thick ice surrounding Antarctica, where it’s dark, subzero and barren. The British Antarctic Survey’s Huw Griffiths reveals how it was spotted unexpectedly in pictures colleagues took with a sub-glacial camera. It’s the stuff of fairy tales – a beautiful cottage, with windows, chimney and floorboards … and supported by a living growing tree. CrowdScience listener Jack wants to know why living houses aren’t a common sight when they could contribute to leafier cities with cleaner air. The UK has an impressive collection of treehouses, but they remain in the realm of novelty, for good reasons. Architects are used to materials like concrete and steel changing over time, but a house built around a living tree needs another level of flexibility in its design. That doesn’t mean it’s impossible and CrowdScience hears about a project in the Ethiopian capital Addis Ababa, where architect Ahadu Abaineh made a three-storey, supported by 4 living Eucalyptus trees as a natural foundation. Host Marnie Chesterton meets some of the global treehouse building fraternity, including builder of over 200 structures, Takashi Kobayashi, who adapts his houses to the Japanese weather. In Oregon, USA, Michael Garnier has built an entire village of treehouses for his “Treesort”. He’s developed better ways of building , including the Tree Attachment Bolt, which holds the weight of the house while minimising damage to the tree. Professor Mitchell Joachim from Terreform One explains the wild potential of living architecture, a movement which looks at organic ways of building. He’s currently building a prototype living house, by shaping willow saplings onto a scaffold that will become a home, built of live trees. (Image: A man walks to his friend's home in a neighbourhood without electricity as snow covers the BlackHawk neighborhood in Pflugerville, Texas, U.S. Credit: Reuters)

On 18th February the Perseverance rover should land on Mars. Katie Stack-Morgan of NASA’s Jet Propulsion Lab tells Roland Pease about the technological advances that mean that the spacecraft should be able to land in Jezero Crater. Imperial College geologist Sanjeev Gupta discusses what this crater can reveal about the history of life on the red planet. After months of negotiations, and weeks of work on the ground, a team brought together by the World Health Organisation has just concluded its first attempts to find out the origins of SARS-Cov2 in Wuhan. Peter Daszak, who has worked closely with Chinese virologists in the past, briefed Roland Pease on what had been discovered. The South African government has announced that it will not be rolling out the Astra Zeneca Covid vaccine as it appears it is not very effective against the dominant strain in the country. Helen Rees, of Witwatersrand University and a member of South Africa’s Health Products Regulatory Authority, explains that the ‘ban’ is an overstatement. At least 35 people died in a flood disaster in the Himalayan state of Uttarakhand in India on February 6th. The details are still unclear, but the trigger seems to be associated with a glacier overhanging an upstream lake in the steep valley. Rupert Stuart-Smith of Oxford University, who has just published an analysis of a glacier melting disaster in waiting in the Andes, talks about the impacts of climate change on the stability of mountain glaciers. And Do you find your bearings quickly or are you easily disorientated? Do your friends trust you with the directions in a new city? Finding our way in the physical world – whether that’s around a building or a city - is an important everyday capability, one that has been integral to human survival. This week CrowdScience listeners want to know whether some people are ‘naturally’ better at navigating, so presenter Marnie Chesterton sets her compass and journeys into the human brain. Accompanied by psychologists and neuroscientists Marnie learns how humans perceive their environment, recall routes and orientate themselves in unfamiliar spaces. We ask are some navigational strategies better than others? Marnie also hears that the country you live in might be a good predictor of your navigation skills and how growing up in the countryside may give you an wayfaring advantage. But is our navigational ability down to biology or experience, and can we improve it? With much of our modern map use being delegated to smartphones, Marnie explores what implications an over-reliance on GPS technology might have for our brain health. (Image: An illustration of NASA’s Perseverance rover landing on Mars. Credit NASA/JPL-Caltech) Presenter: Roland Pease Producer: Deborah Cohen

A new trial is about to start in the UK, seeing if different vaccines can be mixed and matched in a two-dose schedule, and whether the timing matters. Governments want to know the answer as vaccines are in short supply. Oxford University’s Matthew Snape takes Roland Pease through the thinking. Despite the numbers of vaccines being approved for use we still need treatments for Covid-19. A team at the University of North Carolina is upgrading the kind of manufactured antibodies that have been used to treat patients during the pandemic, monoclonal antibodies. Lisa Gralinski explains how they are designing souped-up antibodies that’ll neutralise not just SARS-CoV-2, but a whole range of coronaviruses. Before global warming, the big ecological worry that exercised environmentalists was acid rain. We’d routinely see pictures of forests across the world dying because of the acid soaking they’d had poisoning the soil. In a way, this has been one of environmental activism’s success stories. The culprit was sulphur in coal and in forecourt fuels – which could be removed, with immediate effect on air quality. But biogeochemist Tobias Goldhammer of the Leibniz Institute in Berlin and colleagues have found that sulphur, from other sources, is still polluting water courses. There’s been debate over when and where dogs became man’s best friend. Geoff Marsh reports on new research from archaeology and genetics that puts the time at around 20,000 years ago and the place as Siberia. Could being happier help us fight infectious disease? As the world embarks on a mass vaccination programme to protect populations from Covid-19, Crowdscience asks whether our mood has any impact on our immune systems. In other words, could being happier help us fight infectious diseases? Marnie Chesterton explores how our mental wellbeing can impact our physical health and hears that stress and anxiety make it harder for our natural defence systems to kick in – a field known as psychoneuroimmunology. Professor Kavita Vedhara from the University of Nottingham explains flu jabs are less successful in patients with chronic stress. So scientists are coming up with non-pharmacological ways to improve vaccine efficiency. We investigate the idea that watching a short feel-good video before receiving the inoculation could lead to increased production of antibodies to a virus. And talk to Professor Richard Davidson who says mindfulness reduces stress and makes vaccines more effective.

Northern white rhinos are extinct in the wild and there are just two females in captivity in Kenya. Conservationists are working on an artificial breeding programme, using eggs from the females and sperm from a deceased male. Now five embryos have been created. Thomas Hildebrandt of the Leibniz Institute for Zoo and Wildlife Research in Berlin explained the research. President Biden’s first executive order was what’s being called the hundred-day mask mandate. The day before the inauguration a massive analysis of mask-wearing and COVID rates demonstrated a clear, if small, benefit. Epidemiologist Ben Rader told Roland Pease that it got over 300,000 opinions by using the online questionnaire, SurveyMonkey. After the alarming series of record-breaking heatwaves last year, global warming is causing specific problems in the innumerable lakes around the world. Lakes are ecologically particularly vulnerable to extremes. The European Space Agency’s Yestyn Woolway has been analysing past trends, and modelling the future. 2020 delivered a record year in hurricanes, which caused around $60 billion dollars in damage to the US alone, according to one estimate. A new technology called Airborne Phased-Array Radar promises to improve the measurements that are currently made by planes that fly right into the eye of the hurricanes, and make the missions safe. It’s being developed at the National Centre for Atmospheric Research and Roland discussed the new technology with the Director of NCAR, Vanda Grubišić. And Covid-19 has prompted a cleaning frenzy. CrowdScience listener William works as a personal trainer in a gym, and while cleaning’s always been part of his job, it’s now taken over much of his working day. He’s constantly wiping down equipment and doing regular deep cleans, and he reckons he can sanitize his hands 40 times in one shift. This kind of routine might strike a chord with many of us, and it’s certainly vital to take hygiene seriously during times of pandemic. But could there be any downsides to all this extra cleaning? There’s a whole world of microbes out there: some, like SARS-CoV-2, make us sick, but others are essential for our health. A rich microbiome is linked to a healthy immune system, while ‘good’ microbes help keep ‘bad’ ones at bay. And what about the chemicals in cleaning products – do they have any unintended consequences for our health? CrowdScience turns to the experts to ask whether our supercharged hygiene routines could damage our immune systems, or promote the spread of superbugs. And we hear why, as long as we have a good diet, plenty of fresh air, and ideally a furry pet, we don’t need to worry too much about being too clean. (Image; Najin and Fatu, the only two remaining female northern white rhinos graze in their paddock. Credit: Tony Karumba/AFP via Getty Images)